VIRTUAL SCREENING OF PEPTIDE AND PEPTIDOMIMETIC FRAGMENTS TARGETED TO INHIBIT BACTERIAL DITHIOL OXIDASE DSBA.

Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA.

Antibacterial drugs with novel scaffolds and new mechanisms of Nail action are desperately needed to address the growing problem of antibiotic resistance.The periplasmic oxidative folding system in Gram-negative bacteria represents a possible target for anti-virulence antibacterials.By targeting virulence rather than viability, development of resis

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CARICATURE AS A MEANS TO FORM AND REFLECT THE "ENEMY IMAGE" IN WORLD WAR I (BASED ON MATERIALS OF RUSSIAN PERIODICALS 1916)

This article analyzes the subjects of caricature of military problems during the First World War.By 1916 Bulgaria had joined the allied bloc of Germany, and in connection with this the caricature images of the "enemy" in the pages of the Russian ORG AMARANTH press are gaining popularity new subjects, mostly related to the image of relations between

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Evaluation of Statistical Treatment of Left-Censored Contamination Data: Example Involving Deoxynivalenol Occurrence in Pasta and Pasta Substitute Products

The handling of data on food contamination frequently represents a challenge because these are often left-censored, being composed of both positive and non-detected values.The latter observations are not quantified and provide only the information that they are below a laboratory-specific threshold value.Besides deterministic approaches, which simp

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